Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens—but the multi-day half-life of ADC leads to high exposure even of normal, antigen-free, tissues...

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Publicado en:Protein Eng Des Sel
Autores principales: Lipovšek, Daša, Carvajal, Irvith, Allentoff, Alban J, Barros, Anthony, Brailsford, John, Cong, Qiang, Cotter, Pete, Gangwar, Sanjeev, Hollander, Cris, Lafont, Virginie, Lau, Wai Leung, Li, Wenying, Moreta, Miguel, O’Neil, Steven, Pinckney, Jason, Smith, Michael J, Su, Julie, Terragni, Christina, Wallace, Michael A, Wang, Lifei, Wright, Martin, Marsh, H Nicholas, Bryson, James W
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158766/
https://ncbi.nlm.nih.gov/pubmed/30247737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy013
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