Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule

Glioblastoma multiforme is one of the most aggressive brain tumors and current therapies with temozolomide or suberoylanilide hydroxamic acid (SAHA, vorinostat) show considerable limitations. SAHA is a histone deacetylase (HDAC) inhibitor that can cause undesirable side effects due to the lack of se...

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Vydáno v:Cell Death Discov
Hlavní autoři: Zhang, Issan, Beus, Maja, Stochaj, Ursula, Le, Phuong Uyen, Zorc, Branka, Rajić, Zrinka, Petrecca, Kevin, Maysinger, Dusica
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158288/
https://ncbi.nlm.nih.gov/pubmed/30302275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0103-0
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