SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial activity, and PQ, an antimalarial drug with low antiproliferative activit...

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Veröffentlicht in:ChemistryOpen
Hauptverfasser: Beus, Maja, Rajić, Zrinka, Maysinger, Dusica, Mlinarić, Zvonimir, Antunović, Maja, Marijanović, Inga, Fontinha, Diana, Prudêncio, Miguel, Held, Jana, Olgen, Sureyya, Zorc, Branka
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104433/
https://ncbi.nlm.nih.gov/pubmed/30151334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800117
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