SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial activity, and PQ, an antimalarial drug with low antiproliferative activit...

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Beus, Maja, Rajić, Zrinka, Maysinger, Dusica, Mlinarić, Zvonimir, Antunović, Maja, Marijanović, Inga, Fontinha, Diana, Prudêncio, Miguel, Held, Jana, Olgen, Sureyya, Zorc, Branka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104433/
https://ncbi.nlm.nih.gov/pubmed/30151334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800117
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