SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents

We report the synthesis of SAHAquines and related primaquine (PQ) derivatives. SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial activity, and PQ, an antimalarial drug with low antiproliferative activit...

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Publicado en:ChemistryOpen
Autores principales: Beus, Maja, Rajić, Zrinka, Maysinger, Dusica, Mlinarić, Zvonimir, Antunović, Maja, Marijanović, Inga, Fontinha, Diana, Prudêncio, Miguel, Held, Jana, Olgen, Sureyya, Zorc, Branka
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104433/
https://ncbi.nlm.nih.gov/pubmed/30151334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201800117
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