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Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection

Cellular susceptibility to viral infections is in part determined by the presence of a host cellular receptor. Here we use murine norovirus as a model to uncover an unappreciated connection between an intracellular lipid biosynthetic enzyme and a receptor conformation permissive for viral infection....

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Bibliografske podrobnosti
izdano v:Nat Microbiol
Main Authors: Orchard, Robert C., Wilen, Craig B., Virgin, Herbert W.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158067/
https://ncbi.nlm.nih.gov/pubmed/30127493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0221-8
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