A neoepitope derived from a novel human germline APC gene mutation in familial adenomatous polyposis shows selective immunogenicity

Familial adenomatous polyposis (FAP) is an inherited condition arising from genetic defects in the Adenomatous polyposis coli (APC) gene. Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into colon cancer. In this study, we identified a...

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Pubblicato in:PLoS One
Autori principali: Majumder, Snigdha, Shah, Rakshit, Elias, Jisha, Mistry, Yogesh, Coral, Karunakaran, Shah, Priyanka, Maurya, Anand Kumar, Mittal, Bharti, D’Silva, Jason K., Murugan, Sakthivel, Mahadevan, Lakshmi, Sathian, Rekha, Ramprasad, V. L., Chakraborty, Papia, Gupta, Ravi, Chaudhuri, Amitabha, Khanna-Gupta, Arati
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157866/
https://ncbi.nlm.nih.gov/pubmed/30256815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203845
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