A neoepitope derived from a novel human germline APC gene mutation in familial adenomatous polyposis shows selective immunogenicity

Familial adenomatous polyposis (FAP) is an inherited condition arising from genetic defects in the Adenomatous polyposis coli (APC) gene. Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into colon cancer. In this study, we identified a...

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Publicat a:PLoS One
Autors principals: Majumder, Snigdha, Shah, Rakshit, Elias, Jisha, Mistry, Yogesh, Coral, Karunakaran, Shah, Priyanka, Maurya, Anand Kumar, Mittal, Bharti, D’Silva, Jason K., Murugan, Sakthivel, Mahadevan, Lakshmi, Sathian, Rekha, Ramprasad, V. L., Chakraborty, Papia, Gupta, Ravi, Chaudhuri, Amitabha, Khanna-Gupta, Arati
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157866/
https://ncbi.nlm.nih.gov/pubmed/30256815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203845
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