Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

PURPOSE: This study is aimed at preparing and testing physicochemical, pharmacokinetic and levels of toxic metabolites of paracetamol and glucosamine solid dispersions intended for multiple deliveries via the parenteral or per oral route. METHODS: Solid dispersions were prepared using the spray dryi...

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Dades bibliogràfiques
Publicat a:Drug Des Devel Ther
Autors principals: Ali, Ahmed Mahmoud Abdelhaleem, Khames, Ahmed, Alrobaian, Majed Mansour, Hamaidi, Mohammad, Abourehab, Mohammed AS
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2018
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157577/
https://ncbi.nlm.nih.gov/pubmed/30275684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S176099
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