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Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

PURPOSE: This study is aimed at preparing and testing physicochemical, pharmacokinetic and levels of toxic metabolites of paracetamol and glucosamine solid dispersions intended for multiple deliveries via the parenteral or per oral route. METHODS: Solid dispersions were prepared using the spray dryi...

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Detaylı Bibliyografya
Yayımlandı:Drug Des Devel Ther
Asıl Yazarlar: Ali, Ahmed Mahmoud Abdelhaleem, Khames, Ahmed, Alrobaian, Majed Mansour, Hamaidi, Mohammad, Abourehab, Mohammed AS
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157577/
https://ncbi.nlm.nih.gov/pubmed/30275684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S176099
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