Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

PURPOSE: This study is aimed at preparing and testing physicochemical, pharmacokinetic and levels of toxic metabolites of paracetamol and glucosamine solid dispersions intended for multiple deliveries via the parenteral or per oral route. METHODS: Solid dispersions were prepared using the spray dryi...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Ali, Ahmed Mahmoud Abdelhaleem, Khames, Ahmed, Alrobaian, Majed Mansour, Hamaidi, Mohammad, Abourehab, Mohammed AS
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157577/
https://ncbi.nlm.nih.gov/pubmed/30275684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S176099
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