Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides

An RNase H-dependent antisense oligonucleotide (ASO), having the 2′-O-(2-N-methylcarbamoylethyl) (MCE) modification, was evaluated in vitro and in vivo. The antisense activities of an ASO having the MCE modification were comparable with those of an ASO having the 2′-O-methoxyethyl (MOE) modification...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acid Ther
Autori principali: Masaki, Yoshiaki, Iriyama, Yusuke, Nakajima, Hiroyuki, Kuroda, Yusuke, Kanaki, Tatsuro, Furukawa, Satoshi, Sekine, Mitsuo, Seio, Kohji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157346/
https://ncbi.nlm.nih.gov/pubmed/30020852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2018.0738
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