טוען...
Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides
An RNase H-dependent antisense oligonucleotide (ASO), having the 2′-O-(2-N-methylcarbamoylethyl) (MCE) modification, was evaluated in vitro and in vivo. The antisense activities of an ASO having the MCE modification were comparable with those of an ASO having the 2′-O-methoxyethyl (MOE) modification...
שמור ב:
| הוצא לאור ב: | Nucleic Acid Ther |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Mary Ann Liebert, Inc., publishers
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6157346/ https://ncbi.nlm.nih.gov/pubmed/30020852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2018.0738 |
| תגים: |
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