Linear Relationship between Deformability and Thermal Stability of 2′-O-Modified RNA Hetero Duplexes

[Image: see text] We describe the relationship between the experimentally determined melting temperatures of 2′-O-modified-RNA/RNA duplexes and their deformability estimated from molecular dynamics simulations. To clarify this relationship, we synthesized several fully modified oligoribonucleotides...

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Hauptverfasser: Masaki, Yoshiaki, Miyasaka, Ryuta, Ohkubo, Akihiro, Seio, Kohji, Sekine, Mitsuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2010
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825091/
https://ncbi.nlm.nih.gov/pubmed/20108976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp909851j
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