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Computational modeling of synergistic interaction between αVβ3 integrin and VEGFR2 in endothelial cells: implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides
Cooperation between VEGFR2 and integrin αVβ3 is critical for neovascularization in wound healing, cardiovascular ischemic diseases, ocular diseases, and tumor angiogenesis. In the present study, we developed a rule- based computational model to investigate the potential mechanism by which the Src-in...
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| Publicado no: | J Theor Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156791/ https://ncbi.nlm.nih.gov/pubmed/30036530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2018.06.029 |
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