Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of vascular endothelial growth factor (VEGF). The molecular mechanism of this inhibition is not entirely clear. We developed a det...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S., Annex, Brian H., Popel, Aleksander S.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988849/
https://ncbi.nlm.nih.gov/pubmed/29899706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00644
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