Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of vascular endothelial growth factor (VEGF). The molecular mechanism of this inhibition is not entirely clear. We developed a det...

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Detalles Bibliográficos
Publicado en:Front Physiol
Autores principales: Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S., Annex, Brian H., Popel, Aleksander S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988849/
https://ncbi.nlm.nih.gov/pubmed/29899706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00644
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