Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis. Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of vascular endothelial growth factor (VEGF). The molecular mechanism of this inhibition is not entirely clear. We developed a det...

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Bibliografski detalji
Izdano u:Front Physiol
Glavni autori: Bazzazi, Hojjat, Zhang, Yu, Jafarnejad, Mohammad, Isenberg, Jeffrey S., Annex, Brian H., Popel, Aleksander S.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Physiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988849/
https://ncbi.nlm.nih.gov/pubmed/29899706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00644
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