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Nrf1 can be processed and activated in a proteasome-independent manner

Vangala et al. demonstrate that the ER-bound transcription factor Nrf1 can be proteolytically cleaved and activated when the proteasome is completely inhibited, thus pointing to the existence of a proteasome-independent pathway to generate functional Nrf1.

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Bibliografiske detaljer
Udgivet i:Curr Biol
Main Authors: Vangala, Janakiram R., Sotzny, Franziska, Krüger, Elke, Deshaies, Raymond J., Radhakrishnan, Senthil K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156719/
https://ncbi.nlm.nih.gov/pubmed/27676297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.08.008
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