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Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex
Inhibition of the proteasome leads to proteotoxic stress, which is characterized by the buildup of ubiquitinated proteins that cannot be degraded properly. The transcription factor Nrf1 (also called NFE2L1) counteracts proteotoxic stress by inducing transcription of proteasome subunit genes, resulti...
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| Publicado en: | J Biol Chem |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6369275/ https://ncbi.nlm.nih.gov/pubmed/30559296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006290 |
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