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14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis
The Ciona notochord has emerged as a simple and tractable in vivo model for tubulogenesis. Here, using a chemical genetics approach, we identified UTKO1 as a selective small molecule inhibitor of notochord tubulogenesis. We identified 14-3-3εa protein as a direct binding partner of UTKO1 and showed...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6156656/ https://ncbi.nlm.nih.gov/pubmed/30158171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808756115 |
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