Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

Nitric Oxide (NO) is an intracellular signalling mediator, which affects many biological processes via the posttranslational modification of proteins through S-nitrosation. The availability of NO and NOS-derived reactive oxygen species (ROS) from enzymatic uncoupling are determined by the NO synthas...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Bailey, Jade, Davis, Simon, Shaw, Andrew, Diotallevi, Marina, Fischer, Roman, Benson, Matthew A., Zhu, Hanneng, Brown, James, Bhattacharya, Shoumo, Kessler, Benedikt M., Channon, Keith M., Crabtree, Mark J.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156325/
https://ncbi.nlm.nih.gov/pubmed/30254268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32481-4
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