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Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation

The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins. The conjugation machinery consists of the bispecific...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bialas, Johanna, Groettrup, Marcus, Aichem, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359146/
https://ncbi.nlm.nih.gov/pubmed/25768649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120329
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