The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation

FAT10 is a ubiquitin-like modifier that directly targets proteins for proteasomal degradation. Here, we report the high-resolution structures of the two individual ubiquitin-like domains (UBD) of FAT10 that are joined by a flexible linker. While the UBDs of FAT10 show the typical ubiquitin-fold, the...

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Publicado en:Nat Commun
Main Authors: Aichem, Annette, Anders, Samira, Catone, Nicola, Rößler, Philip, Stotz, Sophie, Berg, Andrej, Schwab, Ricarda, Scheuermann, Sophia, Bialas, Johanna, Schütz-Stoffregen, Mira C., Schmidtke, Gunter, Peter, Christine, Groettrup, Marcus, Wiesner, Silke
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102260/
https://ncbi.nlm.nih.gov/pubmed/30127417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05776-3
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