Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y(12) signaling with MRS2395

The release of ADP from platelet dense granules and its binding to platelet P2Y(12) receptors is key to amplifying the initial haemostatic response and propagating thrombus formation. P2Y(12) has thus emerged as a therapeutic target to safely and effectively prevent secondary thrombotic events in pa...

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Bibliographische Detailangaben
Veröffentlicht in:Platelets
Hauptverfasser: Mitrugno, Annachiara, Rigg, Rachel A., Laschober, Nicole B., Ngo, Anh T.P., Pang, Jiaqing, Williams, Craig D., Aslan, Joseph E., McCarty, Owen J.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155984/
https://ncbi.nlm.nih.gov/pubmed/28523947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09537104.2017.1316482
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