Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites

Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates–Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible a...

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Publicat a:Molecules
Autors principals: Galaka, Tamila, Ferrer Casal, Mariana, Storey, Melissa, Li, Catherine, Chao, María N., Szajnman, Sergio H., Docampo, Roberto, Moreno, Silvia N. J., Rodriguez, Juan B.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155738/
https://ncbi.nlm.nih.gov/pubmed/28054995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22010082
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