In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites

We tested a series of sulfur-containing linear bisphosphonates against Toxoplasma gondii, the etiologic agent of toxoplasmosis. The most potent compound (compound 22; 1-[(n-decylsulfonyl)ethyl]-1,1-bisphosphonic acid) is a sulfone-containing compound, which had a 50% effective concentration (EC(50))...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Szajnman, Sergio H., Galaka, Tamila, Li, Zhu-Hong, Li, Catherine, Howell, Nathan M., Chao, María N., Striepen, Boris, Muralidharan, Vasant, Moreno, Silvia N. J., Rodriguez, Juan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278718/
https://ncbi.nlm.nih.gov/pubmed/27895021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01590-16
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