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Synthetic Approaches to Mono- and Bicyclic Perortho-Esters with a Central 1,2,4-Trioxane Ring as the Privileged Lead Structure in Antimalarial and Antitumor-Active Peroxides and Clarification of the Peroxide Relevance

The synthesis of 4-styryl-substituted 2,3,8-trioxabicyclo[3.3.1]nonanes, peroxides with the core structure of the bioactive 1,2,4-trioxane ring, was conducted by a multistep route starting from the aryl methyl ketones 1a–1c. Condensation and reduction/oxidation delivered enals 4a–4c that were couple...

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Publicat a:Molecules
Autors principals: Griesbeck, Axel G., Bräutigam, Maria, Kleczka, Margarethe, Raabe, Angela
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155645/
https://ncbi.nlm.nih.gov/pubmed/28085079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22010119
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