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Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks

Homologous recombination (HR) is a crucial pathway for the repair of DNA double-strand breaks. BRCA1/2 breast cancer proteins are key players in HR via their mediation of RAD51 nucleofilament formation and function; however, their individual roles and crosstalk in vivo are unknown. Here we use super...

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Publicat a:Nat Commun
Autors principals: Whelan, Donna R., Lee, Wei Ting C., Yin, Yandong, Ofri, Dylan M., Bermudez-Hernandez, Keria, Keegan, Sarah, Fenyo, David, Rothenberg, Eli
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155164/
https://ncbi.nlm.nih.gov/pubmed/30250272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06435-3
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