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Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma

Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting...

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Pubblicato in:Mol Cell Oncol
Autori principali: Saei, Azad, Eichhorn, Pieter Johan Adam
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154850/
https://ncbi.nlm.nih.gov/pubmed/30263945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1497862
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