Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma

BACKGROUND: Melanoma is a heterogeneous tumour, but the impact of this heterogeneity upon therapeutic response is not well understood. METHODS: Single cell mRNA analysis was used to define the transcriptional heterogeneity of melanoma and its dynamic response to BRAF inhibitor therapy and treatment...

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Publicado en:EBioMedicine
Main Authors: Smalley, Inna, Kim, Eunjung, Li, Jiannong, Spence, Paige, Wyatt, Clayton J., Eroglu, Zeynep, Sondak, Vernon K., Messina, Jane L., Babacan, Nalan Akgul, Maria-Engler, Silvya Stuchi, De Armas, Lesley, Williams, Sion L., Gatenby, Robert A., Chen, Y. Ann, Anderson, Alexander R.A., Smalley, Keiran S.M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
Assuntos:
Research paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838387/
https://ncbi.nlm.nih.gov/pubmed/31594749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.023
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