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Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK

The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effective small molecule inhibitors for both therape...

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Bibliografske podrobnosti
izdano v:	Molecules
Main Authors:	Halekotte, Jakob, Witt, Lydia, Ianes, Chiara, Krüger, Marc, Bührmann, Mike, Rauh, Daniel, Pichlo, Christian, Brunstein, Elena, Luxenburger, Andreas, Baumann, Ulrich, Knippschild, Uwe, Bischof, Joachim, Peifer, Christian
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI 2017
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6154583/ https://ncbi.nlm.nih.gov/pubmed/28338621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22040522
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Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK

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