Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK

The involvement of protein kinase CK1δ in the pathogenesis of severe disorders such as Alzheimer’s disease, amyotrophic lateral sclerosis, familial advanced sleep phase syndrome, and cancer has dramatically increased interest in the development of effective small molecule inhibitors for both therape...

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Détails bibliographiques
Publié dans:Molecules
Auteurs principaux: Halekotte, Jakob, Witt, Lydia, Ianes, Chiara, Krüger, Marc, Bührmann, Mike, Rauh, Daniel, Pichlo, Christian, Brunstein, Elena, Luxenburger, Andreas, Baumann, Ulrich, Knippschild, Uwe, Bischof, Joachim, Peifer, Christian
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154583/
https://ncbi.nlm.nih.gov/pubmed/28338621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22040522
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