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Aim for the Core: Suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Neurodegenerative diseases are a class of age-associated proteopathies characterized by the accumulation of misfolded and/or aggregation-prone proteins. This imbalance has been attributed, in part, to an age-dependent decay in the capacity of protein turnover. Most proteins are degraded by the ubiqu...
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| Publicado no: | Transl Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6154511/ https://ncbi.nlm.nih.gov/pubmed/30244692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trsl.2018.05.002 |
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