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Preparation of a Crystalline Salt of Indomethacin and Tromethamine by Hot Melt Extrusion Technology
Although salt formation is the most ubiquitous and effective method of increasing the solubility and dissolution rates of acidic and basic drugs, it consumes large quantities of organic solvents and is a batch process. Herein, we show that the dissolution rate of indomethacin (a poorly water-soluble...
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| Publicado no: | Eur J Pharm Biopharm |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6154477/ https://ncbi.nlm.nih.gov/pubmed/30086393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2018.08.001 |
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