3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways

3,4-Dihydroxybenzalactone (DBL) was isolated from Phellinus linteus (PL), which is a folk medicine possessing various physiological effects. In this study, we used highly metastatic A549 cells to investigate efficacy of DBL inhibition of cancer metastasis and possible mechanisms. The results reveale...

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Bibliographic Details
Published in:Molecules
Main Authors: Chao, Wei, Deng, Jeng-Shyan, Li, Pei-Ying, Liang, Yu-Chia, Huang, Guan-Jhong
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6154291/
https://ncbi.nlm.nih.gov/pubmed/28350337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22040537
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