Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide

Background The hexapeptide 4A6 (Ac-Thr(tBu)-His(Bzl)-Thr(Bzl)-Nle-Glu(OtBu)-Gly-Bza) was isolated from a peptide library constructed to identify peptide-based transport inhibitors of multidrug resistance (MDR) efflux pumps including P-glycoprotein and Multidrug Resistance-associated Protein 1. 4A6 p...

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Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Oerlemans, Ruud, Berkers, Celia R., Assaraf, Yehuda G., Scheffer, George L., Peters, Godefridus J., Verbrugge, Sue Ellen, Cloos, Jacqueline, Slootstra, Jerry, Meloen, Rob H., Shoemaker, Robert H., Dijkmans, Ben A. C., Scheper, Rik J., Ovaa, Huib, Jansen, Gerrit
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
Assuntos:
Preclinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153520/
https://ncbi.nlm.nih.gov/pubmed/29442210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0569-x
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