Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures

Intra-tumor heterogeneity represents a major barrier to anti-cancer therapies. One strategy to minimize this limitation relies on bystander effects via diffusion of cytotoxins from targeted cells. Hypoxia-activated prodrugs (HAPs) have the potential to exploit hypoxia in this way, but robust methods...

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Publicat a:Front Pharmacol
Autors principals: Hong, Cho R., Bogle, Gib, Wang, Jingli, Patel, Kashyap, Pruijn, Frederik B., Wilson, William R., Hicks, Kevin O.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153434/
https://ncbi.nlm.nih.gov/pubmed/30279659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01013
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