The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104

Activation of prodrugs in tumors (e.g., by bioreduction in hypoxic zones) has the potential to generate active metabolites that can diffuse within the tumor microenvironment. Such “bystander effects” may offset spatial heterogeneity in prodrug activation but the relative importance of this effect is...

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Main Authors: Foehrenbacher, Annika, Patel, Kashyap, Abbattista, Maria R., Guise, Chris P., Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791487/
https://ncbi.nlm.nih.gov/pubmed/24109591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00263
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