Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells

DNA methyltransferase 3A (DNMT3A) is mutated in various myeloid neoplasms including acute myeloid leukemia (AML), especially at the Arg882 and associated with inferior outcomes. Here, we report that the DNMT3A-Arg882His/Cys (R882H/C) mutations led to inactivation of apoptosis through DNA damage sign...

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Vydáno v:Neoplasia
Hlavní autoři: Bera, Rabindranath, Chiu, Ming-Chun, Huang, Ying-Jung, Liang, Der-Cherng, Lee, Yun-Shien, Shih, Lee-Yung
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2018
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Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153424/
https://ncbi.nlm.nih.gov/pubmed/30245403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.08.013
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