Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome–Like Sensorimotor Defects

Rett syndrome (RTT) is caused in most cases by loss-of-function mutations in the X-linked gene encoding methyl CpG-binding protein 2 (MECP2). Understanding the pathological processes impacting sensory-motor control represents a major challenge for clinical management of individuals affected by RTT,...

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Vydáno v:eNeuro
Hlavní autoři: Morello, Noemi, Schina, Riccardo, Pilotto, Federica, Phillips, Mary, Melani, Riccardo, Plicato, Ornella, Pizzorusso, Tommaso, Pozzo-Miller, Lucas, Giustetto, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2018
Témata:
New Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153339/
https://ncbi.nlm.nih.gov/pubmed/30255129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0086-18.2018
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