Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex

Cyclin-dependent kinase-like 5 (CDKL5) mutations are found in severe neurodevelopmental disorders, including the Hanefeld variant of Rett syndrome (RTT; CDKL5 disorder). CDKL5 loss-of-function murine models recapitulate pathological signs of the human disease, such as visual attention deficits and r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Cell Neurosci
Prif Awduron: Pizzo, Riccardo, Gurgone, Antonia, Castroflorio, Enrico, Amendola, Elena, Gross, Cornelius, Sassoè-Pognetto, Marco, Giustetto, Maurizio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2016
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124713/
https://ncbi.nlm.nih.gov/pubmed/27965538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00261
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