Lack of Cdkl5 Disrupts the Organization of Excitatory and Inhibitory Synapses and Parvalbumin Interneurons in the Primary Visual Cortex

Cyclin-dependent kinase-like 5 (CDKL5) mutations are found in severe neurodevelopmental disorders, including the Hanefeld variant of Rett syndrome (RTT; CDKL5 disorder). CDKL5 loss-of-function murine models recapitulate pathological signs of the human disease, such as visual attention deficits and r...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Pizzo, Riccardo, Gurgone, Antonia, Castroflorio, Enrico, Amendola, Elena, Gross, Cornelius, Sassoè-Pognetto, Marco, Giustetto, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5124713/
https://ncbi.nlm.nih.gov/pubmed/27965538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00261
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