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“Mallostery”—ligand-dependent protein misfolding enables physiological regulation by ERAD
HMG-CoA reductase (HMGR) undergoes regulated degradation as part of feedback control of the sterol pathway. In yeast, the stability of the HMGR isozyme Hmg2 is controlled by the 20-carbon isoprenoid geranylgeranyl pyrophosphate (GGPP). Increasing GGPP levels cause more efficient degradation by the H...
Enregistré dans:
| Publié dans: | J Biol Chem |
|---|---|
| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153289/ https://ncbi.nlm.nih.gov/pubmed/30018140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001808 |
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