TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p–dependent down-regulation of cGMP-dependent kinase 1

cGMP-dependent protein kinase 1 (PKG1) plays an important role in nitric oxide (NO)/cGMP–mediated maintenance of vascular smooth muscle cell (VSMC) phenotype and vasorelaxation. Inflammatory cytokines, including tumor necrosis factor-α (TNFα), have long been understood to mediate several inflammator...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Choi, Seunghwan, Park, Minsik, Kim, Joohwan, Park, Wonjin, Kim, Suji, Lee, Dong-Keon, Hwang, Jong Yun, Choe, Jongseon, Won, Moo-Ho, Ryoo, Sungwoo, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Young-Myeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6153283/
https://ncbi.nlm.nih.gov/pubmed/30104414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004220
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