Robust activation of microhomology-mediated end joining for precision gene editing applications

One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathway. Such unpredictability limits the utility of som...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ata, Hirotaka, Ekstrom, Thomas L., Martínez-Gálvez, Gabriel, Mann, Carla M., Dvornikov, Alexey V., Schaefbauer, Kyle J., Ma, Alvin C., Dobbs, Drena, Clark, Karl J., Ekker, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152997/
https://ncbi.nlm.nih.gov/pubmed/30208061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007652
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