A new drug combination significantly reduces kidney tumor progression in kidney mouse model

Tuberous sclerosis complex (TSC) disease is associated with tumors in many organs, particularly angiomyolipoma (AML) in the kidneys. Loss or inactivation of TSC1/2 results in high levels of HIF-α activity and VEGF expression. mTOR inhibitor (rapamycin) and the AMPK activator 5-aminoimidazole-4-carbo...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Liang, Sitai, Cuellar, Tiffanie, Nowacki, Maciej, Nayak, Bijaya K., Dong, Lily, Li, Boajie, Sharma, Kumar, Habib, Samy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152473/
https://ncbi.nlm.nih.gov/pubmed/30250638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26004
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