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A new drug combination significantly reduces kidney tumor progression in kidney mouse model

Tuberous sclerosis complex (TSC) disease is associated with tumors in many organs, particularly angiomyolipoma (AML) in the kidneys. Loss or inactivation of TSC1/2 results in high levels of HIF-α activity and VEGF expression. mTOR inhibitor (rapamycin) and the AMPK activator 5-aminoimidazole-4-carbo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liang, Sitai, Cuellar, Tiffanie, Nowacki, Maciej, Nayak, Bijaya K., Dong, Lily, Li, Boajie, Sharma, Kumar, Habib, Samy L.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152473/
https://ncbi.nlm.nih.gov/pubmed/30250638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26004
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