Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one...

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Dades bibliogràfiques
Publicat a:RNA Biol
Autors principals: Asrani, Kirtika H., Farelli, Jeremiah D., Stahley, Mary R., Miller, Rebecca L., Cheng, Christopher J., Subramanian, Romesh R., Brown, Jeffrey M.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152433/
https://ncbi.nlm.nih.gov/pubmed/29578372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1450054
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