Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:RNA Biol
Asıl Yazarlar: Asrani, Kirtika H., Farelli, Jeremiah D., Stahley, Mary R., Miller, Rebecca L., Cheng, Christopher J., Subramanian, Romesh R., Brown, Jeffrey M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152433/
https://ncbi.nlm.nih.gov/pubmed/29578372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1450054
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