Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one...

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Detalles Bibliográficos
Publicado en:RNA Biol
Autores principales: Asrani, Kirtika H., Farelli, Jeremiah D., Stahley, Mary R., Miller, Rebecca L., Cheng, Christopher J., Subramanian, Romesh R., Brown, Jeffrey M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152433/
https://ncbi.nlm.nih.gov/pubmed/29578372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1450054
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