Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:RNA Biol
Main Authors: Asrani, Kirtika H., Farelli, Jeremiah D., Stahley, Mary R., Miller, Rebecca L., Cheng, Christopher J., Subramanian, Romesh R., Brown, Jeffrey M.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152433/
https://ncbi.nlm.nih.gov/pubmed/29578372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1450054
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