Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

mRNA based therapies hold great promise for the treatment of genetic diseases. However, this therapeutic approach suffers from multiple challenges including the short half-life of exogenously administered mRNA and subsequent protein production. Modulation of untranslated regions (UTR) represents one...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Asrani, Kirtika H., Farelli, Jeremiah D., Stahley, Mary R., Miller, Rebecca L., Cheng, Christopher J., Subramanian, Romesh R., Brown, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6152433/
https://ncbi.nlm.nih.gov/pubmed/29578372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2018.1450054
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