Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

A series of isoniazid derivatives bearing a phenolic or heteroaromatic coupled frame were obtained by mechanochemical means. Their pH stability and their structural (conformer/isomer) analysis were checked. The activity of prepared derivatives against Mycobacterium tuberculosis cell growth was evalu...

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Publié dans:Molecules
Auteurs principaux: Oliveira, Paulo F. M., Guidetti, Brigitte, Chamayou, Alain, André-Barrès, Christiane, Madacki, Jan, Korduláková, Jana, Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent Roberto, Pasca, Maria Rosalia, Lherbet, Christian, Carayon, Chantal, Massou, Stéphane, Baron, Michel, Baltas, Michel
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151834/
https://ncbi.nlm.nih.gov/pubmed/28862683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22091457
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