Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice

PURPOSE: The main purpose of this study was to formulate an oil-in-water nanoemulsion of a next generation taxoid DHA-SBT-1214 and evaluate its biodistribution and pharmacokinetics. METHODS: DHA-SBT-1214 was encapsulated in a fish oil containing nanoemulsion using a high pressure homogenization meth...

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Bibliographic Details
Published in:Pharm Res
Main Authors: Ahmad, Gulzar, Gattacecca, Florence, El Sadda, Rana, Botchkina, Galina, Ojima, Iwao, Egan, James, Amiji, Mansoor
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151135/
https://ncbi.nlm.nih.gov/pubmed/29520477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2349-x
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