New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

BACKGROUND: Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and resistance to drugs. Previously we have shown that the CD133(high)/CD44(high )fr...

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Détails bibliographiques
Auteurs principaux: Botchkina, Galina I, Zuniga, Edison S, Das, Manisha, Wang, Yuan, Wang, Hichao, Zhu, Shu, Savitt, Anne G, Rowehl, Rebecca A, Leyfman, Yan, Ju, Jingfang, Shroyer, Kenneth, Ojima, Iwao
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911448/
https://ncbi.nlm.nih.gov/pubmed/20630067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-192
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