Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells

Two novel peptides belonging to the dermaseptin family, namely DRS-CA-1 and DRS-DU-1, were encoded from cDNA libraries derived from the skin secretions of Phyllomedusa camba and Callimedusa (Phyllomedusa) duellmani. Both natural peptides are highly-conserved and exhibited high potency against wild-t...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Zhu, Haohao, Ding, Xiyan, Li, Wei, Lu, Tulin, Ma, Chengbang, Xi, Xinping, Wang, Lei, Zhou, Mei, Burden, Roberta, Chen, Tianbao
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2018
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6151122/
https://ncbi.nlm.nih.gov/pubmed/30258724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.5635
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