Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates

DMPC-10A (ALWKKLLKK-Cha-NH(2)) is a 10-mer peptide derivative from the N-terminal domain of Dermaseptin-PC which has shown broad-spectrum antimicrobial activity as well as a considerable hemolytic effect. In order to reduce hemolytic activity and improve stability to endogenous enzymes, a D-amino ac...

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Bibliographic Details
Published in:Antibiotics (Basel)
Main Authors: Zai, Yu, Ying, Yuan, Ye, Zhuming, Zhou, Mei, Ma, Chengbang, Shi, Zhanzhong, Chen, Xiaoling, Xi, Xinping, Chen, Tianbao, Wang, Lei
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557582/
https://ncbi.nlm.nih.gov/pubmed/32967333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antibiotics9090627
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